Role of Steroids and Other Immunomodulators in Treatment of COVID-19

Coronavirus disease 2019(COVID- 19), the newly discovered infectious is caused by an infection with a novel virus belonging to family Coronaviridae named severe acute respiratory syndrome coronavirus-2(SARS-CoV-2). SARS-CoV-2-infected cells produce substances that can induce injury lung as focus of initiation COVID-19 during incubation period. These bind receptors on target cells. Corticosteroids specific intracellular cytoplasmic in tissues. The receptor hormone recruits co-activator or co-repressor proteins after dimerizing. In patients develop systemic inflammatory response leads and multisystem organ dysfunction. Even though evidence consistently supporting use steroids ARDS pneumonia hard come potent anti-inflammatory effects are postulated prevent deleterious inflammation seen COVID pneumonia. A monoclonal antibody cocktail consisting Casirivimab Imdevimab another promising therapeutic option at high risk deterioration. Used early process they hospitalization further morbidity.